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8 Amazing Wrinkle-Fighting Supplements for Anti-Aging

by Beverly Hills MD

June 25 2016

It’s no secret. As we age, our skin does too. Signs of aging start to appear on our faces in the form of fine lines, wrinkles, and dark spots. And that can be really upsetting, especially if it feels like it happened overnight when a certain big birthday descended.

But, what if there was a way to combat this?

Thanks to modern science, innovative anti-aging skincare AND supplements can help decrease the appearance of Father Time on our faces.

Since you probably have your skincare routine down to a science, you can fight wrinkles internally as well. Here are eight of the most effective anti-aging supplements:


Biotin is a water-soluble vitamin. In humans, it serves as a coenzyme – but it’s usually taken as a supplement because humans can’t naturally synthesize biotin by themselves.1

This vitamin may help to stop cell death – which is what causes our skin to age.2 Could biotin keep the skin as supple and firm as it was in our teens and twenties? Well, we can always dream, but it can help slow the signs of aging on the skin.

Consider adding a biotin supplement to your daily routine. The recommended daily dose for adolescents and adults is 30-100 micrograms per day. But, it’s safe to supplement with much more (of course, consult your doctor before starting any new supplement program).

CollagenWrinkle-Fighting Supplements | Beverly Hills MD

Collagen is considered a primary structural component of our skin. A loss of collagen is believed to be a direct cause of wrinkles. Replacing this collagen is incredibly important to help fight signs of aging (especially fine lines and wrinkles).4
Our bodies produce collagen naturally. Over time, however, collagen production declines. The collagen we do still have in our skin can become deformed and disorganized. How fast does this collagen depletion happen? Research suggests collagen content per unit area of skin declines about one percent each year.5

If you’re looking to stimulate collagen production by adding supplements to your diet, a recommended dose would depend on your age, weight, diet, and other factors, so consult your doctor to be sure.

Hyaluronic Acid

Hyaluronic acid (HA) is a molecule known for its strong water-binding potential. It’s believed to help maintain the skin’s elasticity and moisture – which is why it’s a key player in the fight against wrinkles.6
Adding a moisturizer with HA could mean the difference between having dewy skin or dry skin – especially since our natural production of HA decreases over time as we age.7

It’s approved for serums, creams, and lotions, so getting access to HA can be as easy as picking up an anti-aging serum.

If you choose to add an HA supplement, the recommended dose is 100 mg per day.8

Polypodium Leucotomos Extract (PLE)

An extract commonly seen in pill form, PLE is suggested to protect against sun damage, discoloration, and sagging skin. The extract, derived from a Central American fern, is believed to protect skin cells that build and restore collagen within the dermis.9

PLE is a mixture of phytochemicals that are packed with antioxidant properties. It’s believed that PLE protects the skin against harmful UV rays by stopping the reaction in our skin that causes sunburns, while also preventing photoaging (another way wrinkles can develop).10

While most experts agree that you should never ditch your sunscreen in favor for other methods, PLE can be used as a possible supplement to protect the skin against further damage.

A recommended dose of PLE is considered to be 500 mg before sun exposure.11

Wrinkle-Fighting Supplements | Beverly Hills MD

Vitamin C

Sure, you may get a nice dose of Vitamin C with your morning OJ, but this powerful antioxidant can also be incredibly beneficial to skin. Vitamin C is believed to protect against the appearance of wrinkles and aging by preventing cell damage.12

Vitamin C is also suggested to be essential for collagen production by influencing, regulating, and stimulating collagen molecules within the skin. As if this isn’t amazing enough, vitamin C also has anti-inflammatory properties that can protect the skin against hyperpigmentation and other causes linked to the development of wrinkles.13
For best results, a recommended dose of vitamin C is 100 mg per day.14

Vitamin E

Vitamin E is said to work best with vitamin C, but that doesn’t mean it doesn’t have some benefits of its own.15

It too has anti-inflammatory properties and is believed to protect against environmental skin damage. Both roles are important in skin regeneration and cell production, which can regulate skin health, helping to keep the complexion radiant and reducing signs of wrinkles.16

Further research suggests that Vitamin E has specific photoprotective properties as well. Some sources of the vitamin include nuts, spinach, and olive oil. Vitamin E is known for helping a wide variety of dermatological issues.17

For maximum benefit, the recommended dose for vitamin E is 200 IU per day.18

(IU, or international unit, measures fat soluble vitamins. The conversion of IU to mg depends on the nutrient.)


Normally used as a topical ingredient, glucosamine is suggested to help reduce the signs of wrinkles in study participants who ingested the amino acid. It’s also believed to hydrate skin, and it may help to accelerate wound healing.19
Glucosamine, in combination with other compounds, is believed to reduce the amount of melanin in skin cells, helping to improve skin tone and reducing the appearance of dark spots.20
A recommended dose of glucosamine is 1,500 mg per day for ultimate hydration.21

Coenzyme Q10

Often referred to as CoQ10, coenzyme Q10 is similar to Vitamins C and E. It too is believed to help maintain skin health. It may work to reduce the depth, volume, and size of wrinkles.22

CoQ10 has been linked to reducing cell and DNA damage caused by UVA radiation in human skin cells. By hindering cell damage and stimulating protein production, CoQ10 may protect the skin while rejuvenating wrinkles simultaneously.23

To get wrinkle-reducing benefits, try the recommended CoQ10 dose of 1,500 mg per day.24

All-in-One Anti-Aging Supplement

Wrinkle-Fighting Supplements | Beverly Hills MD

Aging may be inevitable, but that doesn’t mean that we can’t fight the signs of aging on our faces. Adding innovative anti-aging supplements like collagen and hyaluronic acid, in combination with vitamins like E and CoQ10, can mean the difference between looking 50 and looking 30. But what if you’re already maxed out on the amount of vitamins you can handle taking per day, we’ve created a solution. Dermal Repair Complex is an all-in-one anti-aging supplement that’s packed with wrinkle-fighting nutrients.

You’ve been doing your part to slow the signs of aging topically with your skincare regime. Now it’s time to take care of your skin from the inside out.


1Zempleni J, Wijeratne S, Hassan Y. Biotin. 2009. Accessed November 22, 2016.
2 Zempleni J, Wijeratne S, Hassan Y. Biotin. 2009. Accessed November 22, 2016.
4 Ganceviciene R, Liakou A, Theodoridis A, Makrantonaki E, Zouboulis C. Skin anti-aging strategies. 2012.
5 Ganceviciene R, Liakou A, Theodoridis A, Makrantonaki E, Zouboulis C. Skin anti-aging strategies. 2012.
6  Pavicic T e. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular
Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. 2012. Accessed November 22, 2016.
8 Robinson ARobinson A. How to Retain Hyaluronic Acid in the Body. LIVESTRONGCOM. 2015. Accessed November 22, 2016.
9 5 Anti-Aging Supplements That Work. Prevention. 2015. Accessed November 22, 2016.
10 Gonzalez S e. Mechanistic insights in the use of a Polypodium leucotomos extract as an oral and topical photoprotective agent. – PubMed – NCBI. Ncbinlmnihgov. 2010. Accessed November 22, 2016.
11 Birch J. 2015. Accessed November 22, 2016.
12 Birch J. 2015. Accessed November 22, 2016.
13 Telang P. Vitamin C in dermatology. 2013. Accessed November 22, 2016.
14 Birch J. 2015.Accessed November 22, 2016.
15 Telang P. Vitamin C in dermatology. 2013. Accessed November 22, 2016.
16  Birch J. 2015. Accessed November 22, 2016.
17Keen MHassan I. Vitamin E in dermatology. 2016. Accessed November 22, 2016.
18 Birch J. 2015. Accessed November 22, 2016.
19 Birch J. 2015. Accessed November 22, 2016.
20  Sarkar R, Arora P, Garg K. Cosmeceuticals for hyperpigmentation: What is available?. 2013. Accessed November 22, 2016.
21 Birch J. 2015. Accessed November 22, 2016.
22 Birch J. 2015. Accessed November 22, 2016.
23 Inui M e. Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. – PubMed – NCBI. Ncbinlmnihgov. 2008. Accessed November 22, 2016.
24 Birch J. 2015. Accessed November 22, 2016.

Beverly Hills MD Dermal Repair Complex